This paper reports an experimental study of the use of cyanoacrylate adhesives to prevent adhesions between tissues, rather than to glue tissues together. This paradoxical procedure is based on the two factors possessed by the adhesives of tissue barrier action and lack of biodegradation. Films of the liquid adhesive were placed between muscle and globe and between globe and overlying conjunctiva, allowed to polymerize, and then tissues were reapposed. No adhesions developed between these tissues so separated. Clinical application of this effect in strabismus surgery and in filtration surgery for glaucoma has obvious importance. Use in selected patients having strabismus has been started; use in glaucoma surgery requires further laboratory investigation.
Dunlap EA, Dunn M, Rossomondo R. New Uses for Ocular Adhesives. Arch Ophthalmol. 1969;82(6):756-760. doi:10.1001/archopht.1969.00990020748006