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January 1970

Fluorescein Angiography of Choroidal Melanomas

Author Affiliations

Los Angeles
From the departments of ophthalmology (Drs. Pettit, Christensen, and Barton) and pathology (Dr. Foos) and Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles.

Arch Ophthalmol. 1970;83(1):27-38. doi:10.1001/archopht.1970.00990030029006

Thirty-six patients with intraocular malignant melanomas were studied using fluorescein angiography. Of these, 86% demonstrated a pattern characterized by gradually increasing fluorescence which starts at or before the arterial phase, increases in intensity well into the recirculation phase, and persists for at least 45 minutes. Five of 36 melanomas studied did not conform to this pattern. Analysis of these five cases revealed that heavy pigmentation of the tumor and subretinal hemorrhage or exudate obscured the expected fluorescence. Fourteen patients with benign melanoma of the choroid, with and without drusen, were also studied by fluorescein angiography.