The effects of the single instillation in one eye of topically applied isoproterenol hydrochloride in concentrations of 5%, 2.5%, and 1.25% were evaluated in patients with ocular hypertension. Dose related reductions in intraocular pressure were found which were maximal six hours after the instillation and lasted for 12 to 62 hours. Tonography done at the time of maximal drug effect showed no reduction in resistance to aqueous outflow. Of those studied, 50% showed tachycardia of over 100 beats per minute on one or more occasions, with associated palpitations or weakness. The significance of the findings and side effects was discussed.
Ross RA, Drance SM. Effects of Topically Applied Isoproterenol on Aqueous Dynamics in Man. Arch Ophthalmol. 1970;83(1):39-46. doi:10.1001/archopht.1970.00990030041007