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Article
February 1970

SILICONE IMPREGNATION OF THE CORNEAL STROMA

Author Affiliations

Winston-Salem, NC

Arch Ophthalmol. 1970;83(2):257. doi:10.1001/archopht.1970.00990030259020

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Abstract

To the Editor.  —For cases of severe corneal disease ordinarily not amenable to corneal homografting, many types of plastic corneal implants are being evaluated. Unfortunately solid prosthetic devices placed into a diseased cornea are subject to extrusion, erosion of the surrounding cornea, leakage of aqueous humor, pyogenic infection, and toxic reaction to impurities and breakdown products of the methyl methacrylate polymer.My approach to the problems of prosthetic corneal surgery has been to develop a donor cornea treated in such a way as to impregnate the tissue with liquid silicone. The process yields a full thickness corneal stroma which is clear, swells very little with prolonged exposure to water, and has a strong rubbery structure which sutures easily to host tissues.Briefly, the processes employed for siliconization of the cornea are as follows: Mucopolysaccharides are partially removed by papain digestion and sodium acetate extraction. Water is removed by lyophilization (rapid

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