Continuous treatment with mestranol, 0.1 mg/ day, in normal women, caused a small gradually growing intraocular pressure decrease of 2.0 ± 0.45 mm Hg and an outflow facility increase of 0.085μl ± 0.015μl (min mm Hg)-1 at six months. Treatment of another group of 15 normal women with mestranol + ethynodiol diacetate in doses of 0.1 mg and 1.0 mg per day, respectively, gave similar results. The decrease in intraocular pressure was 1.8 ± 0.38 mm Hg at six months, and the increase in outflow facility was 0.056μl ± 0.01μl (min mm Hg)-1 at six months. In both groups, the effect of the drugs on intraocular pressure and outflow facility was highly significant (P < 0.001). However, the differences between the two groups were not significant. Reasons are presented for the belief that the drugs act on the trabecular meshwork.
Treister G, Mannor S. Intraocular Pressure and Outflow FacilityEffect of Estrogen and Combined Estrogen-Progestin Treatment in Normal Human Eyes. Arch Ophthalmol. 1970;83(3):311-318. doi:10.1001/archopht.1970.00990030313008