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March 1970

Chronic Fluoride Ingestion in RabbitsAbsence of Ocular Effects

Author Affiliations

Iowa City
From the ERG Laboratory of the Department of Ophthalmology, and the Neurosensory Center, College of Medicine, University of Iowa, Iowa City.

Arch Ophthalmol. 1970;83(3):354-356. doi:10.1001/archopht.1970.00990030354014

Twenty rabbits received large doses of orally administered fluoride for 3 to 5 months. Baseline and subsequent electroretinogram (ERG) and ophthalmoscopic examinations were done on each rabbit as well as on a group of control rabbits. Although bone concentrations of fluoride were compatible with chronic system fluorosis, there were no significant differences in the ERGs, fundi, or microscopic sections of the treated eyes as compared to the control eyes.