Collagen deposition in healing stromal wounds under limbus-based flaps was studied in nine human eyes obtained postmortem from 1 to 46 days after senile cataract extraction. Collagen was present under the flap in the five day specimen, but was not seen bridging the stromal wound except in specimens 15 days or longer after surgery. In the 46 day specimen stromal wound collagen was still not mature or well remodeled. A unique specimen obtained only 25 hours after cataract extraction by cryoprobe with enzymatic zonulolysis had endothelial damage and stromal edema related to inadvertent corneal cryo-adhesion. Zonule entrapment and iris wound exudate were found, in addition to other interesting histological findings. Clinical implications are discussed.
Flaxel JT. Histology of Cataract Extractions. Arch Ophthalmol. 1970;83(4):436-444. doi:10.1001/archopht.1970.00990030436008