Early degeneration of the rabbit retina after hemoglobin injection into the vitreous was studied by light and electron microscopy. Structural changes including a pyknotic change in rod nuclei and early rod degeneration were apparent three days after injection. Electron-dense bodies began to appear within the degenerating pigment epithelium cells on the seventh day. These bodies may be degenerating products of outer rod segments.
Vitreous Hemorrhage: An Experimental StudyIII. Experimental Degeneration of the Rabbit Retina Induced by Hemoglobin Injection Into the Vitreous. Arch Ophthalmol. 1970;83(4):470-474. doi:10.1001/archopht.1970.00990030470016