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June 1970

Studies on Experimental Ocular Toxoplasmosis in the RabbitI. The Effect of Antigenic Stimulation

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, and Department of Ophthalmology, University of California San Francisco Medical Center.

Arch Ophthalmol. 1970;83(6):724-728. doi:10.1001/archopht.1970.00990030724010

Attempts to stimulate recurrent inflammation in the eyes of rabbits with experimentally induced toxoplasmic retinochoroiditis by the injection of Toxoplasma antigens were unsuccessful. Introduction of living Toxoplasma organisms into the suprachoroidal space of eyes with healed, experimentally induced, toxoplasmic retinochoroiditis resulted in a lowgrade inflammatory response. These experiments provide evidence which contradicts the hypothesis that recurrent toxoplasmic retinochoroiditis results from the leakage of Toxoplasma antigens into the tissues of a hypersensitized eye.