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June 1970

Ocular Studies With Para-chlorophenylalanine in Rats and Monkeys

Author Affiliations

Groton, Conn; Philadelphia
From the Department of Drug Safety Evaluation, Charles Pfizer and Co., Medical Research Laboratory, Groton, Conn (Dr. Gralla), and the School of Veterinary Medicine, University of Pennsylvania, Philadelphia (Dr. Rubin).

Arch Ophthalmol. 1970;83(6):734-740. doi:10.1001/archopht.1970.00990030734012

Weanling rats given a diet containing 300 mg/100 gm para-chlorophenylalanine develop characteristic anterior and posterior lens changes. Approximately 35% continue to complete cataract development and/or a peculiar retractile lens line. Including phenylalanine 1% or 5% to the same diet protects rats against mature cataracts. However, minor lens changes and the refractile line still appear. The absence of any ocular toxicity in monkeys treated with this agent at 300 mg/kg/ day for one year suggests a specific effect only in rats. Mature rats are more resistant to this cataractogenic effect. These lesions do not regress within one year after drug withdrawal.