Twenty-five rabbits were treated with systemic doses of antilymphocyte serum (ALS) or normal horse serum (NHS) prior to the inoculation of the cornea with herpes simplex virus (PH strain). The severity of the clinical response to the virus was enhanced by ALS and even more so by NHS. The possible mechanism responsible for this potentiation were examined. A better model for the production of severe herpes simplex keratitis was established.
Smolin G, Okumoto M. Herpes Simplex KeratitisPotentiation With Normal Horse Serum and Antilymphocyte Serum. Arch Ophthalmol. 1970;83(6):746-751. doi:10.1001/archopht.1970.00990030746014