The effectiveness of guanethidine ophthalmic solution 5% as treatment for endocrine exophthalmos was tested in seven patients in a 14-day double-blind study. The drug produced statistically significant ptosis in three of the seven patients and decreased intraocular pressure in four. Five percent guanethidine solution appears to be a useful agent in the treatment of this difficult ophthalmic disease.
Asregadoo ER. Guanethidine Ophthalmic Solution 5%Use in the Treatment of Endocrine Exophthalmos. Arch Ophthalmol. 1970;84(1):21-24. doi:10.1001/archopht.1970.00990040023006