Evaluation of toxicity in the cyanoacrylate adhesives and their homologs was undertaken in conventional and germ free guinea pigs. Adhesive was applied to the denuded cornea centrally and peripherally and injected intrastromally; all experimental models demonstrated in vivo toxicity. Intrastromal injection and surface application to the central cornea produced the severe inflammatory response in both species.
Aronson SB, McMaster PRB, Moore TE, Coon MA. Toxicity of the Cyanoacrylates. Arch Ophthalmol. 1970;84(3):342-349. doi:10.1001/archopht.1970.00990040344014