A 19-year-old pregnant woman with weight loss and pulmonary infiltrates was found to have metastatic choriocarcinoma. A concomitant marked visual loss was associated with multiple elevated choroidal lesions in both eyes. Treatment with methotrexate resulted in clinical remission and striking improvement of vision and fundus appearance.
Keates RH, Billig SL. Metastatic Uveal ChoriocarcinomaReport of a Case With Improvement After Chemotherapy. Arch Ophthalmol. 1970;84(3):381-384. doi:10.1001/archopht.1970.00990040383020