Systemic or intraocular administration of the double-stranded RNA inducer of interferon, polyinosinic-polycytidilic acid (In•Cn), produced measurable interferon levels in serum, aqueous, and vitreous. Intraocular levels of interferon are greatest with intravenous administration of In•Cn. The injection of In•Cn into either the anterior chamber or vitreous cavity produces significant intraocular levels of interferon, indicating that the eye is a source for interferon production. Highest levels of vitreous interferon were produced after intravitreal injection of In•Cn.
Weissenbacher M, Schachter N, Galin MA, Baron S. Intraocular Production of Interferon. Arch Ophthalmol. 1970;84(4):495-498. doi:10.1001/archopht.1970.00990040497019