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To the Editor.
—I have recently had the opportunity to examine further examples of these tumors, and I, too, have seen free DNA on the lens capsule. Clumps of this substance were also present in subretinal fluid in an early retinoblastoma, with many Flexner-Wintersteiner rosettes arising at the macula in an 8-month-old baby. The diagnosis had been made by chance when the child was in the hospital for another complaint.It is not unlikely that the precipitation of DNA in retinoblastoma as originally reported by me (Lancet2:918, 1968) may be found somewhere in all such cases irrespective of histological grading of clinical staging, and that its deposition, both in the neoplastic areas and on remaining identifiable anatomical structures, is of fortuitous distribution. Serial sections of a large series of cases would be required to get a representative picture.The pursuit of a possible oncological and/or systemic significance of
Mullaney J. REPLY ON DNA PRECIPITATION. Arch Ophthalmol. 1970;84(4):547. doi:10.1001/archopht.1970.00990040549032