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November 1970

Dose Response Analysis of Pilocarpine-Induced Ocular Hypotension

Author Affiliations

New York
From the Department of Ophthalmology, New York Medical College, New York.

Arch Ophthalmol. 1970;84(5):605-608. doi:10.1001/archopht.1970.00990040607008

Single dose loading with pilocarpine hydrochloride concentrations from 1% to 10% was performed in a series of open-angle glaucomatous patients. No significant differences in the ocular hypotensive response occurred at any dose level. On chronic administration, however, 4% pilocarpine produced a significant improvement over the 1% solution in both intraocular pressure and outflow facility. An increase in concentration to 8% produced no additional change in either factor.