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December 1970

Heritability of Ocular Pressure

Author Affiliations

New York; Bethesda, Md; New York
From the Department of Ophthalmology, New York University Medical Center, New York (Dr. Levene), the Human Genetics Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Md (Dr. Workman), and the Division of Human Genetics, Department of Pediatrics, Mount Sinai School of Medicine, New York (Drs. Broder and Hirschhorn). Dr. Broder is a fellow of the Daymon Runyon Cancer Fund.

Arch Ophthalmol. 1970;84(6):730-734. doi:10.1001/archopht.1970.00990040732006

The heritability of ocular pressure in the normal and suspect ranges was studied in 355 individuals consisting of 133 nuclear family groups. The mean pressure between right and left eyes ranged from 10 to 30. There was no definite glaucoma or history of glaucoma in these patients. Heritability is a measure of genetic resemblance between relatives and was defined as the ratio of the additive genetic variance to the observed phenotypic variance. It was calculated from the linear regression and correlation coefficients between first degree relatives. The heritability was significant with an estimated value between 0.40 and 0.50 and a standard error of 0.10.