Intraocular pressure (IOP) changes were studied in normal patients, open-angle glaucoma patients, duodenal ulcer patients, and narrow-angle glaucoma patients, along with pupillary changes in response to oral administration of anticholergenic drugs. Of the 48 normal eye studies, in no case was the IOP rise above normal levels. Only 20 of 94 eyes with open-angle glaucoma had an IOP rise of 4 mm Hg or more. In almost every case, the addition of 1% pilocarpine hydrochloride caused the return of the IOP to normal levels. The ulcer patients demonstrated little appreciable change in IOP or pupil size. The narrow-angle glaucoma group showed only three out of 14 eyes to have a significant rise in IOP. All three, however, returned to normal with the use of locally applied pilocarpine.
Hiatt RL, Fuller IB, Smith L, Swartz J, Risser C. Systemically Administered Anticholinergic Drugs and Intraocular Pressure. Arch Ophthalmol. 1970;84(6):735-740. doi:10.1001/archopht.1970.00990040737007