[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
December 1970

Outer Segments of Photoreceptors and the Retinal Pigment EpitheliumInterrelationship in the Human Eye

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, and Department of Ophthalmology, University of California, San Francisco.

Arch Ophthalmol. 1970;84(6):810-819. doi:10.1001/archopht.1970.00990040812022

The pigment epithelium has two types of processes: (1) relatively slender, fringe-like villi projecting between the outer segments of the photoreceptors, and (2) broad, rampart-like cytoplasmic sheets encompassing the tips of the outer segments. The latter processes play an important role in the normal cohesion between neuroretina and pigment epithelium. In addition, they are capable of phagocytosing the tips of outer segments by protruding inward from all sides. This leads to the formation of pigment epithelial inclusions termed "phagosomes." The phagosomes disintegrate in the pigment epithelium, which results in a change of their morphology. A classification for these morphologically different pigment epithelial inclusions is proposed.