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January 1971

Endogenous Immune UveitisThe Role of Serum Sickness

Author Affiliations

Bethesda, Md
From the National Eye Institute (Dr. Wong and Mr. Anderson), and the Laboratory of Germfree Animal Research, National Institute of Allergy and Infectious Diseases (Dr. McMaster), National Institutes of Health, Department of Health, Education, and Welfare, Bethesda, Md.

Arch Ophthalmol. 1971;85(1):93-102. doi:10.1001/archopht.1971.00990050095015

Evidence is presented that varying degrees of uveitis can be produced experimentally by means of parenteral administrations of horse serum. Hypersensitivity analogous to the tissue injury from antigen-antibody reaction of experimental serum sickness appears to be the pathogenetic mechanism. Renal glomerular lesions were observed along with those seen in the ocular tissues.