Evidence is presented that varying degrees of uveitis can be produced experimentally by means of parenteral administrations of horse serum. Hypersensitivity analogous to the tissue injury from antigen-antibody reaction of experimental serum sickness appears to be the pathogenetic mechanism. Renal glomerular lesions were observed along with those seen in the ocular tissues.
Wong VG, Anderson RR, McMaster PRB. Endogenous Immune UveitisThe Role of Serum Sickness. Arch Ophthalmol. 1971;85(1):93-102. doi:10.1001/archopht.1971.00990050095015