The comparative effects of isosorbide and glycerin on lowering of intraocular tension (IOT) were studied in 54 patients. With isosorbide, a greater fall occurred in 31 patients; while with glycerin, a greater fall occurred in 23. Besides lowering IOT, isosorbide produced significantly fewer side reactions than glycerin.
Mehra KS, Singh R, Char JN, Rajyashree K. Lowering of Intraocular TensionEffects of Isosorbide and Glycerin. Arch Ophthalmol. 1971;85(2):167-168. doi:10.1001/archopht.1971.00990050169009