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February 1971

Eye Changes in Autoimmune NZB and NZB x NZW MiceComparison With Sjögren's Syndrome

Author Affiliations

New York
From the departments of microbiology (Drs. Kessler and Manski) and ophthalmology (Miss Cubberly and Dr. Manski), College of Physicians and Surgeons, Columbia University, New York.

Arch Ophthalmol. 1971;85(2):211-219. doi:10.1001/archopht.1971.00990050213016

All of the 7- to 11-month-old NZB × NZW F1 mice investigated presented ocular changes which, in many respects, are analogous to those associated with Sjögren's syndrome in humans. The lacrimal and the salivary glands showed infiltrations and epimyoepithelial islands; however, lobular architecture was preserved. Superficial erosions of the conjunctival epithelium, thinning of the cornea, and formation of keratin granules in the epithelial cells without cornification were common. Lesions in the anterior chamber, lens, iris, and retina, and a decrease in lacrimation was observed. Many such changes which have not been described in Sjögren's syndrome may be associated with the immunopathological findings in these mice. Enucleation is not warranted in Sjögren's syndrome and therefore histological changes with time are not easily followed in humans.