Interocular protein transfer was demonstrated after intravitreal injection of isotopically labeled bovine serum albumin into one eye of rabbits. The transfer of the trace molecule occurs by a nonhematogenous pathway. These experiments indicate that cerebrospinal fluid route and/or the ipsilateral optic nerve-chiasm-contralateral optic nerve are probably not the pathway mediating nonhematogenous interocular protein transfer.
Hasty ND, Higginbotham RW, Andrews JS, Elliott JH. Nonhematogenous Interocular Protein TransferI. Validity and Possible Routes. Arch Ophthalmol. 1971;85(3):309-314. doi:10.1001/archopht.1971.00990050311014