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March 1971

Nonhematogenous Interocular Protein TransferI. Validity and Possible Routes

Author Affiliations

Nashville, Tenn
From the Division of Ophthalmology (Surgery) and the Ophthalmic Laboratory, Vanderbilt University School of Medicine, Nashville, Tenn.

Arch Ophthalmol. 1971;85(3):309-314. doi:10.1001/archopht.1971.00990050311014

Interocular protein transfer was demonstrated after intravitreal injection of isotopically labeled bovine serum albumin into one eye of rabbits. The transfer of the trace molecule occurs by a nonhematogenous pathway. These experiments indicate that cerebrospinal fluid route and/or the ipsilateral optic nerve-chiasm-contralateral optic nerve are probably not the pathway mediating nonhematogenous interocular protein transfer.