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March 1971

Retrobulbar Administration of Steroids in Herpes Simplex UveitisEfficacy of Treatment in Rabbits

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, Department of Ophthalmology (Drs. Bohigian and Dawson), and the Department of Microbiology (Miss Coleman), University of California, San Francisco.

Arch Ophthalmol. 1971;85(3):320-328. doi:10.1001/archopht.1971.00990050322016

Efficacy of retrobulbar injections of dexamethasone on the von Szily model of herpes simplex chorioretinitis was tested in rabbits. Herpesvirus hominis was injected into the anterior chamber of one eye of 45 rabbits. In each, a uveitis developed in the injected eye. In 36 animals a chorioretinitis appeared 7 to 12 days later in the uninoculated eye. Retrobulbar steroid or placebo therapy was begun in matched animals after clinical signs of posterior chorioretinitis appeared. Eyes were examined daily by an observer not informed of the nature of the treatment. Clinical changes were correlated with photographs, viral titrations, and histologic examinations. A definite anti-inflammatory effect was observed during a short course of retrobulbar steroid therapy, although the final outcome was not altered. This short-term clinical improvement occurred without any significant increase in virus multiplication.