A radioactive assay technique was used to determine the rate of absorption of clotted and unclotted hyphemas in rabbits. Unclotted blood in the anterior chamber was absorbed at a significantly more rapid rate than clotted blood. Treatment of rabbits with clotted hyphemas with intravenous infusions of hyperosmotic urea and mannitol markedly enhanced blood resorption. Subconjunctival injections of methylprednisolone before clotting occurred resulted in poor clot formation and retraction, and thereby enhanced blood resorption. Subconjunctival injections of methylprednisolone after clot formation slightly decreased blood resorption rate.
Masket S, Best M, Fisher LV, Kronenberg SM, Galin MA. Therapy in Experimental Hyphema. Arch Ophthalmol. 1971;85(3):329-333. doi:10.1001/archopht.1971.00990050331018