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March 1971

Topically Applied Steroids in Active Herpes Simplex KeratitisEffect in Rabbits

Author Affiliations

From the departments of ophthalmology (Drs. Takahashi and Leibowitz), microbiology, and medicine (Dr. Kibrick), and the Massachusetts Lions Eye Research Laboratories, Boston University School of Medicine, Boston.

Arch Ophthalmol. 1971;85(3):350-354. doi:10.1001/archopht.1971.00990050352021

Topical administration of medrysone 1.0% produced a detrimental effect on active infection of the corneal epithelium by herpes simplex virus. Treatment with this drug resulted in a keratitis that was more severe in its clinical characteristics and ran a more prolonged course than the disease observed in control animals. A ten-day course of therapy also resulted in a prolongation of the period during which virus could be cultured from the eye. The undesirable effects produced by medrysone 1.0% were not as pronounced as those which followed administration of dexamethasone phosphate 0.1%.