Topical administration of medrysone 1.0% produced a detrimental effect on active infection of the corneal epithelium by herpes simplex virus. Treatment with this drug resulted in a keratitis that was more severe in its clinical characteristics and ran a more prolonged course than the disease observed in control animals. A ten-day course of therapy also resulted in a prolongation of the period during which virus could be cultured from the eye. The undesirable effects produced by medrysone 1.0% were not as pronounced as those which followed administration of dexamethasone phosphate 0.1%.
Takahashi GH, Leibowitz HM, Kibrick S. Topically Applied Steroids in Active Herpes Simplex KeratitisEffect in Rabbits. Arch Ophthalmol. 1971;85(3):350-354. doi:10.1001/archopht.1971.00990050352021