Six weeks following tritiated thymidine labeling of rabbit corneal keratocytes, a 2 to 3 mm central incision was made halfway through the stroma from the endothelial surface. Forty-eight hours following wounding, the globes were enucleated. Radioautography revealed 19.7% ± 10.1% (SD) labeled fibroblasts in the wounded area as compared to 49.6% ± 11.3% (SD) labeled keratocytes in the normal surround. It is suggested that the aqueous humor serves as a significant source of fibroblasts appearing at a small central corneal wound 48 hours after wounding.
Baum JL. Source of the Fibroblast in Central Corneal Wound Healing. Arch Ophthalmol. 1971;85(4):473-477. doi:10.1001/archopht.1971.00990050475014