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April 1971

Source of the Fibroblast in Central Corneal Wound Healing

Author Affiliations

New York
From the Department of Ophthalmology, New York University Medical Center, New York. Dr. Baum is now with the Tufts-New England Medical Center, Boston.

Arch Ophthalmol. 1971;85(4):473-477. doi:10.1001/archopht.1971.00990050475014

Six weeks following tritiated thymidine labeling of rabbit corneal keratocytes, a 2 to 3 mm central incision was made halfway through the stroma from the endothelial surface. Forty-eight hours following wounding, the globes were enucleated. Radioautography revealed 19.7% ± 10.1% (SD) labeled fibroblasts in the wounded area as compared to 49.6% ± 11.3% (SD) labeled keratocytes in the normal surround. It is suggested that the aqueous humor serves as a significant source of fibroblasts appearing at a small central corneal wound 48 hours after wounding.