A patient treated for an inflamed pinguecula with 1% medrysone (HMS) developed a typical delayed hypersensitivity reaction. This was established as a reaction to the medrysone rather than to any of the substances in the vehicle.
Smolin G. Medrysone HypersensitivityReport of a Case. Arch Ophthalmol. 1971;85(4):478-479. doi:10.1001/archopht.1971.00990050480015