The first case of retinal involvement in hereditary hemorrhagic telangiectasia in the American ophthalmic literature shows a marked similarity to diabetic retinopathy. In a patient with the ophthalmoscopic findings of retinal angiopathy and normal glucose tolerance tests, Rendu-Osler-Weber disease, although a rarity, should be considered. The diagnosis can be confirmed by family history of bleeding diathesis and careful inspection of skin and mucous membranes. Cautious photocoagulation therapy merits consideration in such cases.
Davis DG, Smith JL. Retinal Involvement in Hereditary Hemorrhagic Telangiectasia. Arch Ophthalmol. 1971;85(5):618-623. doi:10.1001/archopht.1971.00990050620018