Elevation of intraocular pressure after the topical application of cyloplegic, though rarely noted in the normal population, is seen in some 25% of the open angle glaucomatous population. No positive cycloplegic provocative responses were elicited from a population of 58 normals. After three weeks of treatment with topically administered dexamethasone, however, a 19% incidence of positive cycloplegic provocative tests was found in this same group. No correlation was noted between poststeroid intraocular pressure and cyloplegic-induced pressure elevation, but a statistically significant, inverse correlation between positive cycloplegic responses and outflow facility was noted after steroid treatment. The phenomenon of cycloplegic-induced pressure elevation thus appears to be related more closely to impaired outflow facility than to pretesting intraocular pressure levels.
Harris LS, Galin MA, Mittag TW. Cycloplegic Provocative Testing After Topical Administration of Steroids. Arch Ophthalmol. 1971;86(1):12-14. doi:10.1001/archopht.1971.01000010014003