Fluorometholone 0.1% ophthalmic suspension applied topically was found to be an effective treatment in 308 patients with mild to severe noninfectious inflammatory disorders of the eye. The effect of fluorometholone on intraocular pressure was examined in steroid reactors who had accurately documented histories of pressure responses to prednisolone, dexamethasone, or betamethasone. The drug was also tested in a relatively large random patient population, including many with glaucoma, whose intraocular pressures were observed. The results of these studies indicate that fluorometholone shows a substantially reduced tendency to increase intraocular pressure as compared to several other steroids used topically.
Fairbairn WD, Thorson JC. FluorometholoneAnti-inflammatory and Intraocular Pressure Effects. Arch Ophthalmol. 1971;86(2):138-141. doi:10.1001/archopht.1971.01000010140004