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September 1971

Topically Administered Corticosteroid PreparationsComparison of Intraocular Pressure Effects

Author Affiliations

St. Louis
From the Glaucoma Center, Department of Ophthalmology, and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis.

Arch Ophthalmol. 1971;86(3):251-254. doi:10.1001/archopht.1971.01000010253002

Twenty-eight patients highly responsive to topically administered corticosteroids were subjected to various corticosteroid preparations keeping frequency and duration of administration constant. Topical administration of dexamethasone demonstrated a dose-response relationship for concentrations of 0.1%, 0.005%, and 0.001%. One half of the patients showed greater than 5 mm Hg elevations of intraocular pressure after two to six weeks of therapy with the 20 times dilution (0.005%) of dexamethasone. Dexamethasone 0.001%, hydrocortisone 0.5%, and tetrahydrotriamcinolone 0.25% produced less ocular hypertension. Medrysone 1.0% had the smallest effect on intraocular pressure.