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Article
September 1971

Anomalies of Iris and Anterior-Chamber AngleOccurrence in a Child With Multiple Congenital Anomalies

Author Affiliations

Baltimore; Philadelphia; Bethesda, Md
From the Eye Pathology Laboratory of the departments of pathology and ophthalmology, Johns Hopkins Medical Institutions (Drs. Karlsberg and Green), and the Baltimore City Hospitals (Dr. Emery), Baltimore, the St. Christopher's Hospital for Children, Philadelphia (Dr. Valdes-Depena), and the Section on Experimental Embryology, National Eye Institute, National Institutes of Health, Bethesda, Md (Dr. Coulombre).

Arch Ophthalmol. 1971;86(3):287-292. doi:10.1001/archopht.1971.01000010289009
Abstract

THE PURPOSE of this paper is to report the peculiar ocular histopathologic changes of an anomalous cleavage of the anterior chamber angle, choristomatous cornea-like tissue on the anterior iris surface, and a membrane in the chamber angle in an infant with multiple congenital anomalies.

Report of a Case  This 2-month-old white female infant died at St. Christopher's Hospital for Children on Jan 9, 1967 (autopsy: A-3-67; Wilmer Eye Pathology 29294). The infant's body was grossly malformed, exhibiting generalized asymmetry. The body weighed 2,124 gm (4 lb 10½ oz). The head was markedly flattened on the right side; the fontanel was located above the midportion of the left eyebrow rather than in the midline. The right eye bulged forward considerably. The pupil of the right eye was irregular, and the iris near the pupil had a rim of whitish tissue around it. The left eye was considered normal. The mandible

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