The disappearance of locally-injected 133xenon has been previously established in various tissue and organs as a reliable method for measuring regional blood flow. This paper describes the application of 133Xe disappearance to the measurement of ocular blood flow. Although this method offers definite advantages over other approaches to estimating blood flow in the eye, the actual measurement was considerably less than that of a reference technique. The primary measurement of the 133Xe method, like other methods of in vivo determination, is dependent upon blood flow; however, this measurement cannot be isolated from the influence of other processes, such as the physical diffusion time of 133Xe through the vitreous.
Fish MB, O'Day DM, Aronson SB, Pollycove M. Disappearance of Intravitreous 133XenonIts Relation to Ocular Blood Flow. Arch Ophthalmol. 1971;86(3):314-320. doi:10.1001/archopht.1971.01000010316015