Chronic experimental allergic uveitis was produced in strain XIII guinea pigs following immunization to homologous uveal antigen in seven sequences at two-week intervals. By the end of the final immunization period (day 103), 13 of 19 animals demonstrated active uveal inflammation; eight of these demonstrated moderate or severe disease. After 14 months, 11 of 13 surviving animals demonstrated clinically active uveitis; a majority demonstrated severe disease. The histologic response was characterized by large sheets of lymphoid elements; in more severe reactions; these were interspersed with foci of polymorphonuclear leukocytes. Immunologic testing revealed reactions to uvea, retinovitreous, and lens extracts. The incidence of positivity of uveal antibody increased with time.
Aronson SB, McMaster PRB. Chronic Experimental Allergic Uveitis. Arch Ophthalmol. 1971;86(4):438-442. doi:10.1001/archopht.1971.01000010440014