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Article
October 1971

Chronic Experimental Allergic Uveitis

Author Affiliations

San Francisco; Bethesda, Md
From the Eye Research Laboratories and the Department of Ophthalmology, San Francisco General Hospital, University of California School of Medicine, San Francisco (Dr. Aronson), and the Laboratory of Microbial Immunity, National Institutes of Health, Bethesda, Md (Dr. McMaster).

Arch Ophthalmol. 1971;86(4):438-442. doi:10.1001/archopht.1971.01000010440014
Abstract

Chronic experimental allergic uveitis was produced in strain XIII guinea pigs following immunization to homologous uveal antigen in seven sequences at two-week intervals. By the end of the final immunization period (day 103), 13 of 19 animals demonstrated active uveal inflammation; eight of these demonstrated moderate or severe disease. After 14 months, 11 of 13 surviving animals demonstrated clinically active uveitis; a majority demonstrated severe disease. The histologic response was characterized by large sheets of lymphoid elements; in more severe reactions; these were interspersed with foci of polymorphonuclear leukocytes. Immunologic testing revealed reactions to uvea, retinovitreous, and lens extracts. The incidence of positivity of uveal antibody increased with time.

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