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November 1971

Transient Internal OphthalmoplegiaAreflexia and Methacholine Hypersensitivity With Unidentified Systemic Disease

Author Affiliations

New Haven, Conn
From the Section of Neurology, Yale University School of Medicine, New Haven, Conn.

Arch Ophthalmol. 1971;86(5):595-598. doi:10.1001/archopht.1971.01000010597019

This report describes a reversible, systemic disturbance that included bilateral internal opththalmoplegia, methacholine chloride (Mecholyl) hypersensitivity, and areflexia. Although some aspects of the syndrome have been observed previously (classic Adie's syndrome), the systemic disturbances and reversibility have not been reported previously. The etiology remains obscure.