A 26-year-old white man developed multiple, bilateral, choroidal metastases 11 months after the removal of a cutaneous malignant melanoma. Six weeks later he died. Histopathologic examination of the eyes confirmed the presence of choroidal metastases and revealed a nevus-like configuration at the base of the metastatic lesions. The nerve heads showed cavernous changes identical to those described in early Schnabel's cavernous degeneration, yet there was neither clinical nor histopathological evidence that the eyes were glaucomatous.
Albert DM, Gaasterland DE, Caldwell JBH, Howard RO, Zimmerman LE. Bilateral Metastatic Choroidal Melanoma, Nevi, and Cavernous DegenerationInvolvement of the Optic Nervehead. Arch Ophthalmol. 1972;87(1):39-47. doi:10.1001/archopht.1972.01000020041009