A potent interferon inducer, synthetic polynucleotide complex (poly I:C), was used prophylactically and therapeutically in experimental vaccinial keratoconjunctivitis of rabbits. When topical treatment was begun either 24 hours prior to or one hour after inoculation with vaccinia virus, the poly I:C was highly effective in preventing vaccinial keratoconjunctivitis. When topical treatment was not begun until 24 hours after inoculation, however, its therapeutic efficacy was greatly reduced. Also ineffective was a combined topical and intravenous treatment. The suppressive effect of poly I:C on vaccinial corneal lesions correlated well with the concentration of the virus in the corneal tissue.
Moschini GB, Oh JO. Experimental Vaccinial KeratoconjunctivitisEffect of an Interferon Inducer (Poly I:C). Arch Ophthalmol. 1972;87(2):211-215. doi:10.1001/archopht.1972.01000020213019