The features of the cerebro-hepato-renal (CHR) syndrome, described by Bowen et al in 1964, occurred with ocular involvement. A diagnosis of the ocular signs is discussed, and the possibility of a constant retinal involvement in the CHR syndrome is suggested.
Stanescu B, Dralands L. Cerebro-hepato-renal (Zellweger's) SyndromeOcular Involvement. Arch Ophthalmol. 1972;87(5):590-592. doi:10.1001/archopht.1972.01000020592018