Clinical findings, electrophysiologic studies, and fluorescein angiography are reported in a family pedigree with vitelliform macular degeneration. The electrooculogram is the most useful diagnostic test in this condition. It is also helpful prognostically as an aid in identifying the carrier state. Fluorescein angiography demonstrates a vascular anomaly not previously reported in vitelliform macular degeneration. These may participate in clearing hemorrhage, exudate, and edema from the macular area, resulting in improved visual acuity. The significance of early filling of the superior arterial trunks (noted in two patients) was not determined, but suggests a connection between the choroidal and arterial circulation.
Schwartz LJ, Metz HS, Woodward F. Electrophysiologic and Fluorescein Studies in Vitelliform Macular Degeneration. Arch Ophthalmol. 1972;87(6):636-641. doi:10.1001/archopht.1972.01000020638005