A patient initially presented with an occlusion of a branch of the central retinal artery. Shortly thereafter he developed a central vein obstruction and a swollen optic nerve head. Enucleation and subsequent studies revealed that an adenocarcinoma had metastasized to the optic nerve and that it originated from the prostate gland.
Zappia RJ, Smith ME, Gay AJ. Prostatic Carcinoma Metastatic to Optic Nerve and ChoroidAssociation With Changes Resembling Papilledema. Arch Ophthalmol. 1972;87(6):642-645. doi:10.1001/archopht.1972.01000020644006