Malignant glaucoma is a disease process in which the entire anterior chamber becomes uniformly shallow with forward movement of the lensiris diaphram with pooling of aqueous within or behind the vitreous and elevated intraocular pressure. Classically, this has been described as limited to cases occurring following glaucoma surgery. A case is presented in which malignant glaucoma developed without antecedent surgery. On the basis of this case and a review of similar cases in the literature, it is postulated that miotics can induce malignant glaucoma. The extreme shallowing of the central anterior chamber is the important feature in the clinical recognition of this disease process, differentiating it from pupillary block angle-closure glaucoma.
Rieser JC, Schwartz B. Miotic-Induced Malignant Glaucoma. Arch Ophthalmol. 1972;87(6):706-712. doi:10.1001/archopht.1972.01000020708018