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September 1972

Corneal Anesthetics and Epithelial Oxygen Flux

Author Affiliations

Columbus, Ohio
From the College of Optometry, Ohio State University, Columbus, Ohio.

Arch Ophthalmol. 1972;88(3):305-307. doi:10.1001/archopht.1972.01000030307016

The effects of three topical anesthetics, cocaine, tetracaine (Pontocaine), and benoxinate hydrochloride, on oxygen flux across the tear-epithelial interface were compared in vivo at three dosage levels. Although flux depression did not accompany corneal analgesia in the case of benoxinate, it did occur with both cocaine and tetracaine. In both these cases, analgesia always led flux depression at onset, yet the interrelationship of the two phenomena was not so clearly defined during recovery.