Intravenous infusion of prostaglandin E1 (PGE,) (0.79μg/7.9μI/min) increased intraocular pressure and lowered mean femoral arterial blood pressure in rabbits. These two effects occurred within 20 seconds after the onset of infusion and continued during the ten-minute infusion period. No significant change in outflow facility was found during the PGE, infusion. Topical pretreatment with epinephrine solution (0.5%, 1%, and 2%) antagonized the ocular hypertension produced by intravenous infusion of PGE1.
Chiang TS, Thomas RP. Ocular Hypertension Following Intravenous Infusion of Prostaglandin E1. Arch Ophthalmol. 1972;88(4):418-420. doi:10.1001/archopht.1972.01000030420013