A clinical and pathological study was made of a three-month-old infant with opsoclonus and hydrocephalus. Morphological descriptions of the brain in opsoclonus are available for only eight other cases in the literature; six of these showed parenchymatous changes in the cerebellum, and one showed changes in the hypothalamus, midbrain, and pons. Our patient showed a communicating hydrocephalus and a large cisterna magna, but parenchymatous changes in the cerebellum were absent. There has been no previous report of opsoclonus with otherwise uncomplicated hydrocephalus. The possible role of pressure on the cerebellum by a large cisterna magna or dilated fourth ventricle in the pathogenesis of opsoclonus is discussed.
Shetty T, Rosman NP. Opsoclonus in Hydrocephalus. Arch Ophthalmol. 1972;88(6):585-589. doi:10.1001/archopht.1972.01000030587001