Fungus endophthalmitis was diagnosed on the basis of clinical criteria in two cases of intraocular inflammation that developed within two weeks after uneventful intracapsular cataract extraction. Aqueous humor aspirates revealed inflammatory cells but no fungal forms. Cultures of aqueous humor were negative for fungi in both patients.
In both cases, a steady downhill course was reversed overnight by the episcleral (sub-Tenon's) injection of 5 mg of amphotericin B. Clinical improvement was progressive thereafter. In both cases, visual acuity improved from accurate light projection at the height of inflammation to a final level of 20/20+. A basis for the negative results of microbiological studies is delineated.
Allen HF. Amphotericin B and Exogenous Mycotic Endophthalmitis After Cataract Extraction. Arch Ophthalmol. 1972;88(6):640-644. doi:10.1001/archopht.1972.01000030642014