Two case reports, one clinical and the other pathologic, illustrate important features of optic nerve drusen. A clinical subject demonstrates that optic nerve drusen cause visual field defects and central visual loss in childhood. Another case, studied postmortem, illustrates optic atrophy caused by drusen. Optic nerve drusen may originate from coalescing intracellular deposits of glial cells.
Kamin DF, Hepler RS, Foos RY. Optic Nerve Drusen. Arch Ophthalmol. 1973;89(5):359-362. doi:10.1001/archopht.1973.01000040361001