Ferry reported that in a large series of eyes enucleated because of a visible lesion suspected preoperatively of being a melanoma, 19% were found histopathologically to contain a simulating lesion. The present study was undertaken to update Ferry's data. After the completion of Ferry's study, 5,889 intact eyes were received from October 1962 through December 1969. These were reviewed using Ferry's criteria for selection of cases. Simulating lesions were found responsible for 20% of enucleations for malignant melanoma. Many of the same diagnostic problems continue to plague the ophthalmologist, who often fails to utilize certain diagnostic techniques that are presently available to aid in differential diagnosis.
Shields JA, Zimmerman LE. Lesions Simulating Malignant Melanoma of the Posterior Uvea. Arch Ophthalmol. 1973;89(6):466-471. doi:10.1001/archopht.1973.01000040468004