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June 1973

Vascular Changes in the Anterior Uvea of the Rabbit Produced by Prostaglandins

Author Affiliations

From the Department of Experimental Ophthalmology, Institute of Ophthalmology, London University. Dr. Eakins was on sabbatical leave at the time of this study from the Department of Ophthalmology Research, College of Physicians and Surgeons, Columbia University, New York.

Arch Ophthalmol. 1973;89(6):495-499. doi:10.1001/archopht.1973.01000040497011

The normal vascular pattern of the albino rabbit iris was studied using fluorescein iris angiography. Having established the normal appearances, the technique was used to demonstrate changes in caliber and permeability of the anterior uveal blood vessels after the topical application of prostaglandins E1, E2, and F2α. Changes in intraocular pressure were also recorded. The prostaglandin antagonist, polyphloretin phosphate, administered by subconjunctival injection 30 minutes before the prostaglandin was given was found to antagonize the vasodilation and the increase in permeability normally produced by prostaglandins E1 and E2, and the rise in intraocular pressure produced by all three prostaglandins.