The normal vascular pattern of the albino rabbit iris was studied using fluorescein iris angiography. Having established the normal appearances, the technique was used to demonstrate changes in caliber and permeability of the anterior uveal blood vessels after the topical application of prostaglandins E1, E2, and F2α. Changes in intraocular pressure were also recorded. The prostaglandin antagonist, polyphloretin phosphate, administered by subconjunctival injection 30 minutes before the prostaglandin was given was found to antagonize the vasodilation and the increase in permeability normally produced by prostaglandins E1 and E2, and the rise in intraocular pressure produced by all three prostaglandins.
Whitelocke RAF, Eakins KE. Vascular Changes in the Anterior Uvea of the Rabbit Produced by Prostaglandins. Arch Ophthalmol. 1973;89(6):495-499. doi:10.1001/archopht.1973.01000040497011